Case Author(s): Yungao Ding, MD, PhD and Henry Royal, MD , 5/14/2001 . Rating: #D., #Q.

Diagnosis: Schizencephaly

Brief history:

Man with refractory complex partial seizure


Coronal brain emission image

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View second image(pb). Transaxial brain emission image

View third image(mr). Coronal MRI of the brain

View fourth image(mr). Transaxial MRI of the brain

Full history/Diagnosis is available below

Diagnosis: Schizencephaly

Full history:

26 year old man with left frontoparietal open-lip schizencephaly with overlying polymicrogyria presents with refractory complex partial seizures. Clinical evaluation suggests seizures most likely arising from the left frontal region.


9.0 mCi F-18 FDG, i.v.


A defect in the left frontoparietal cortex is noted corresponding to the open-lip schizencephaly on MRI. The left hemisphere is smaller than that of the right and there is enlargement of the left lateral ventricle as showed on MRI.


Schizencephaly, open- or close-lip, is associated with polymicrogyria/agyria in the adjacent cortex. Patients present with seizure, developmental delay, mental retardation and possible blindness if associated with optic nerve hypoplasia.

ACR Codes and Keywords:

References and General Discussion of PET Brain (Nontumor) Imaging Studies (Anatomic field:Skull and Contents, Category:Normal, Technique, Congenital Anomaly)

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Case number: pb011

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