Case Author(s): J. Wallis, M.D. , 2/23/95 . Rating: #D3, #Q4
Diagnosis: Metastatic Neuroblastoma
Brief history:
4 year old boy with bone pain.
Images:
Anterior and posterior whole body images
View main image(mb) in a separate image viewer
View second image(bs).
Whole body bone scintigraphy (pelvis views
are from 24 hour images)
Full history/Diagnosis is available below
Diagnosis: Metastatic Neuroblastoma
Full history:
Patient who presented with anemia and bone pain.
At the time of the study, final pathology of a bone
marrow biopsy was suspicious for neuroblastoma, but
final stains were pending.
Findings:
Diffuse bone marrow uptake of MIBG suggests widespread
involvement of bone marrow by neuroblastoma.
Normal MIBG activity should be confined to the
heart, salivary glands, liver, spleen, and bladder,
with some excretion into the GI tract.
Bone scintigraphy demonstrated more localized abnormalities,
particularly in the proximal humeri and tibea.
Discussion:
I-131 MIBG is an imaging agent which is useful for the
diagnosis and staging of neuroblastoma and pheochromocytoma.
Other tumors, such as carcinoid and medullary thyroid
carcinoma may be visualized, but with relatively low
sensitivity; octreotide imaging is likely superior for
these tumors.
Followup:
Bone marrow biopsy confirmed neuroblastoma.
ACR Codes and Keywords:
References and General Discussion of MIBG Scintigraphy (Anatomic field:Skeletal System, Category:Neoplasm, Neoplastic-like condition)
Search for similar cases.
Edit this case
Add comments about this case
Read comments about this case
Return to the Teaching File home page.
Case number: mb002
Copyright by Wash U MO
